Harnessing B cells in immunotherapy
نویسندگان
چکیده
منابع مشابه
Harnessing B cells for cancer immunotherapy
B cells are one of the two adaptive arms partnering with T cells in immune defense system against infections by virus, bacteria, fungi and parasites [1]. Originated from hematopoietic stem cells in bone marrow, B cells contain multiple subsets including antibody-secreting cells, antigen-presenting cells (APC), innate B effector cells and regulatory B cells [2]. As a heterogeneous population, B ...
متن کاملHarnessing Human Cross-Presenting CLEC9A+XCR1+ Dendritic Cells for Immunotherapy
1 Mater Research Institute, University of Queensland, Brisbane, QLD, Australia 2 School of Medicine, University of Queensland, Brisbane, QLD, Australia 3 Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia 4 Department of Immunology, Monash University, Melbourne, VIC, Australia 5 School of Biomedical Sciences, University of Queensland, Brisbane, QLD, Australia *Correspon...
متن کاملHarnessing the Microbiome to Enhance Cancer Immunotherapy
The microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT) therapies. We propose innovative treatments that may safely harness the microbiota...
متن کاملDendritic Cells and Their Role in Cancer Immunotherapy
Dendritic cells (DCs) are antigen presenting cells with unique capability to take up and process antigens in the peripheral blood and tissues. They subsequently migrate to draining lymph nodes where they present these antigens and stimulate naive T lympho-cytes. During their life cycle, DCs go through two maturation stages and are referred to as immature and mature cells, respectively. While im...
متن کاملGIFT4-augmented B cells for melanoma immunotherapy
Melanoma is the most dangerous type of skin cancer and one of the fastest growing cancers in the USA. Immunotherapy, by enhancing patient’s immune system, has become an attractive approach for melanoma treatment due to the rapid drug resistance to chemotherapy. B cells are a heterogeneous cell population in the host immune system functionally as antibody-producers, antigen-presenting cells or r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunotherapy
سال: 2016
ISSN: 1750-743X,1750-7448
DOI: 10.2217/imt.15.119